Anticancer agent 277

Anticancer agent 277 (Compound 4a) is an anticancer agent. Anticancer agent 277 has cytotoxic activities against cancer cells. Anticancer agent 277 significantly inhibits hepatocellular carcinoma cells proliferation via arresting S and G2/M phase cell cycle and induces apoptosis by inducing ROS production and elevating apoptosis-related proteins expression. Anticancer agent 277 potently inhibits tumor growth in HepG2 xenograft mice model[1].